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Iomdina, E. N.; Seliverstov, S. V.; Teplyakova, K. O.; Jani, E. V.; Pozdniakova, V. V.; Polyakova, O. N.; Goltsman, G. N. |
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Title |
Terahertz scanning of the rabbit cornea with experimental UVB-induced damage: in vivo assessment of hydration and its verification |
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Journal Article |
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Year |
2021 |
Publication |
J. Biomed. Opt. |
Abbreviated Journal |
J. Biomed. Opt. |
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Volume |
26 |
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4 |
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Keywords |
medicine; scheimpflug imaging; UVB; confocal microscopy; cornea; optical coherent tomography; rabbit eyes; terahertz radiation |
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SIGNIFICANCE: Water content plays a vital role in the normally functioning visual system; even a minor disruption in the water balance may be harmful. Today, no direct method exists for corneal hydration assessment, while it could be instrumental in early diagnosis and control of a variety of eye diseases. The use of terahertz (THz) radiation, which is highly sensitive to water content, appears to be very promising. AIM: To find out how THz scanning parameters of corneal tissue measured by an experimental setup, specially developed for in vivo contactless estimations of corneal reflectivity coefficient (RC), are related to pathological changes in the cornea caused by B-band ultraviolet (UVB) exposure. APPROACH: The setup was tested on rabbit eyes in vivo. Prior to the course of UVB irradiation and 1, 5, and 30 days after it, a series of examinations of the corneal state was made. At the same time points, corneal hydration was assessed by measuring RC. RESULTS: The obtained data confirmed the negative impact of UVB irradiation course on the intensity of tear production and on the corneal thickness and optical parameters. A significant (1.8 times) increase in RC on the 5th day after the irradiation course, followed by a slight decrease on the 30th day after it was revealed. The RC increase measured 5 days after the UVB irradiation course generally corresponded to the increase (by a factor of 1.3) of tear production. RC increase occurred with the corneal edema, which was manifested by corneal thickening (by 18.2% in the middle area and 17.6% in corneal periphery) and an increased volume of corneal tissue (by 17.6%). CONCLUSIONS: Our results demonstrate that the proposed approach can be used for in vivo contactless estimation of the reflectivity of rabbit cornea in the THz range and, thereby, of cornea hydration. |
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National Research University Higher School of Economics, Moscow Institute of Electronics and Mathema, Russia |
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1083-3668 |
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PMID:33834684; PMCID:PMC8027227 |
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1258 |
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Iomdina, E. N.; Goltsman, G. N.; Seliverstov, S. V.; Sianosyan, A. A.; Teplyakova, K. O.; Rusova, A. A. |
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Title |
Study of transmittance and reflectance spectra of the cornea and the sclera in the THz frequency range |
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Journal Article |
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Year |
2016 |
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J. Biomed. Opt. |
Abbreviated Journal |
J. Biomed. Opt. |
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21 |
Issue |
9 |
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97002 (1 to 5) |
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BWO, IMPATT diode, Schottky diode, medicine, animals, cornea, physiology, humans, rabbits, sclera diagnostic imaging, physiology |
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An adequate water balance (hydration extent) is one of the basic factors of normal eye function, including its external shells: the cornea and the sclera. Adequate control of corneal and scleral hydration is very important for early diagnosis of a variety of eye diseases, stating indications for and contraindications against keratorefractive surgeries and the choice of contact lens correction solutions. THz systems of creating images in reflected beams are likely to become ideal instruments of noninvasive control of corneal and scleral hydration degrees. This paper reports on the results of a study involving transmittance and reflectance spectra for the cornea and the sclera of rabbit and human eyes, as well as those of the rabbit eye, in the frequency range of 0.13 to 0.32 THz. The dependence of the reflectance coefficient of these tissues on water mass percentage content was determined. The experiments were performed on three corneas, three rabbit scleras, two rabbit eyes, and three human scleras. The preliminary results demonstrate that the proposed technique, based on the use of a continuous THz radiation, may be utilized to create a device for noninvasive control of corneal and scleral hydration, which has clear potential of broad practical application. |
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Moscow State Pedagogical University, Department of Physics, 29 Malaya Pirogovskaya Street, Moscow 119435, Russia |
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1083-3668 |
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PMID:27626901 |
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1335 |
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Rosfjord, Kristine M.; Yang, Joel K. W.; Dauler, Eric A.; Kerman, Andrew J.; Vikas Anant; Voronov, Boris M.; Gol'tsman, Gregory N.; Berggren, Karl K. |
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Title |
Nanowire Single-photon detector with an integrated optical cavity and anti-reflection coating |
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Journal Article |
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2006 |
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Opt. Express |
Abbreviated Journal |
Opt. Express |
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14 |
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2 |
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527-534 |
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SSPD, SNSPD, cavity |
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We have fabricated and tested superconducting single-photon detectors and demonstrated detection efficiencies of 57% at 1550-nm wavelength and 67% at 1064 nm. In addition to the peak detection efficiency, a median detection efficiency of 47.7% was measured over 132 devices at 1550 nm. These measurements were made at 1.8K, with each device biased to 97.5% of its critical current. The high detection efficiencies resulted from the addition of an optical cavity and anti-reflection coating to a nanowire photodetector, creating an integrated nanoelectrophotonic device with enhanced performance relative to the original device. Here, the testing apparatus and the fabrication process are presented. The detection efficiency of devices before and after the addition of optical elements is also reported. |
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1094-4087 |
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PMID:19503367 |
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388 |
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Kovalyuk, V.; Hartmann, W.; Kahl, O.; Kaurova, N.; Korneev, A.; Goltsman, G.; Pernice, W. H. P. |
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Absorption engineering of NbN nanowires deposited on silicon nitride nanophotonic circuits |
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Journal Article |
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2013 |
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Opt. Express |
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Opt. Express |
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21 |
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19 |
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22683-22692 |
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SSPD, SNSPD, NbN nanoeires, Si3N4 waveguides |
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We investigate the absorption properties of U-shaped niobium nitride (NbN) nanowires atop nanophotonic circuits. Nanowires as narrow as 20nm are realized in direct contact with Si3N4 waveguides and their absorption properties are extracted through balanced measurements. We perform a full characterization of the absorption coefficient in dependence of length, width and separation of the fabricated nanowires, as well as for waveguides with different cross-section and etch depth. Our results show excellent agreement with finite-element analysis simulations for all considered parameters. The experimental data thus allows for optimizing absorption properties of emerging single-photon detectors co-integrated with telecom wavelength optical circuits. |
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1094-4087 |
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PMID:24104155 |
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1213 |
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Shcherbatenko, M.; Lobanov, Y.; Semenov, A.; Kovalyuk, V.; Korneev, A.; Ozhegov, R.; Kazakov, A.; Voronov, B.M.; Goltsman, G.N. |
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Potential of a superconducting photon counter for heterodyne detection at the telecommunication wavelength |
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Journal Article |
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2016 |
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Opt. Express |
Abbreviated Journal |
Opt. Express |
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Volume |
24 |
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26 |
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30474-30484 |
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NbN SSPD mixer, SNSPD |
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Here, we report on the successful operation of a NbN thin film superconducting nanowire single-photon detector (SNSPD) in a coherent mode (as a mixer) at the telecommunication wavelength of 1550 nm. Providing the local oscillator power of the order of a few picowatts, we were practically able to reach the quantum noise limited sensitivity. The intermediate frequency gain bandwidth (also referred to as response or conversion bandwidth) was limited by the spectral band of a single-photon response pulse of the detector, which is proportional to the detector size. We observed a gain bandwidth of 65 MHz and 140 MHz for 7 x 7 microm2 and 3 x 3 microm2 devices, respectively. A tiny amount of the required local oscillator power and wide gain and noise bandwidths, along with unnecessary low noise amplification, make this technology prominent for various applications, with the possibility for future development of a photon counting heterodyne-born large-scale array. |
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1094-4087 |
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PMID:28059394 |
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1207 |
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Elezov, M.; Ozhegov, R.; Goltsman, G.; Makarov, V. |
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Countermeasure against bright-light attack on superconducting nanowire single-photon detector in quantum key distribution |
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Journal Article |
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2019 |
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Opt. Express |
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Opt. Express |
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27 |
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21 |
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30979-30988 |
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SSPD, SNSPD |
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We present an active anti-latching system for superconducting nanowire single-photon detectors. We experimentally test it against a bright-light attack, previously used to compromise security of quantum key distribution. Although our system detects continuous blinding, the detector is shown to be partially blindable and controllable by specially tailored sequences of bright pulses. Improvements to the countermeasure are suggested. |
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1094-4087 |
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PMID:31684339 |
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1275 |
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Mohan, N.; Minaeva, O.; Gol'tsman, G. N.; Nasr, M. B.; Saleh, B. E.; Sergienko, A. V.; Teich, M. C. |
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Photon-counting optical coherence-domain reflectometry using superconducting single-photon detectors |
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Journal Article |
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2008 |
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Opt. Express |
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Opt. Express |
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16 |
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22 |
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18118-18130 |
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SSPD, SNSPD |
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We consider the use of single-photon counting detectors in coherence-domain imaging. Detectors operated in this mode exhibit reduced noise, which leads to increased sensitivity for weak light sources and weakly reflecting samples. In particular, we experimentally demonstrate the possibility of using superconducting single-photon detectors (SSPDs) for optical coherence-domain reflectometry (OCDR). These detectors are sensitive over the full spectral range that is useful for carrying out such imaging in biological samples. With counting rates as high as 100 MHz, SSPDs also offer a high rate of data acquisition if the light flux is sufficient. |
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Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. nm82@bu.edu |
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PMID:18958090 |
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1407 |
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Nasr, M. B.; Minaeva, O.; Goltsman, G. N.; Sergienko, A. V.; Saleh, B. E.; Teich, M. C. |
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Submicron axial resolution in an ultrabroadband two-photon interferometer using superconducting single-photon detectors |
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Journal Article |
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2008 |
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Opt. Express |
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Opt. Express |
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16 |
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19 |
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15104-15108 |
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SSPD, SNSPD |
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We generate ultrabroadband biphotons via the process of spontaneous parametric down-conversion in a quasi-phase-matched nonlinear grating that has a linearly chirped poling period. Using these biphotons in conjunction with superconducting single-photon detectors (SSPDs), we measure the narrowest Hong-Ou-Mandel dip to date in a two-photon interferometer, having a full width at half maximum (FWHM) of approximately 5.7 fsec. This FWHM corresponds to a quantum optical coherence tomography (QOCT) axial resolution of 0.85 µm. Our results indicate that a high flux of nonoverlapping biphotons may be generated, as required in many applications of nonclassical light. |
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Departments of Electrical & Computer Engineering and Physics, Quantum Imaging Laboratory, Boston University, Boston, MA 02215, USA. boshra@bu.edu |
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1094-4087 |
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PMID:18795048 |
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1408 |
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Vodolazov, D. Y.; Korneeva, Y. P.; Semenov, A. V.; Korneev, A. A.; Goltsman, G. N. |
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Vortex-assisted mechanism of photon counting in a superconducting nanowire single-photon detector revealed by external magnetic field |
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2015 |
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Phys. Rev. B |
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Phys. Rev. B |
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92 |
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10 |
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104503 (1 to 9) |
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SSPD, SNSPD |
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We use an external magnetic field to probe the detection mechanism of a superconducting nanowire single-photon detector. We argue that the hot belt model (which assumes partial suppression of the superconducting order parameter Δ across the whole width of the superconducting nanowire after absorption of the photon) does not explain observed weak-field dependence of the photon count rate (PCR) for photons with λ=450nm and noticeable decrease of PCR (with increasing the magnetic field) in a range of the currents for photons with wavelengths λ=450–1200nm. Found experimental results for all studied wavelengths can be explained by the vortex hot spot model (which assumes partial suppression of Δ in the area with size smaller than the width of the nanowire) if one takes into account nucleation and entrance of the vortices to the photon induced hot spot and their pinning by the hot spot with relatively large size and strongly suppressed Δ. |
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1098-0121 |
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1343 |
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Lusche, R.; Semenov, A.; Korneeva, Y.; Trifonov, A.; Korneev, A.; Gol'tsman, G.; Hübers, H.-W. |
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Effect of magnetic field on the photon detection in thin superconducting meander structures |
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Journal Article |
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2014 |
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Phys. Rev. B |
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Phys. Rev. B |
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89 |
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10 |
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104513 (1 to 7) |
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NbN SSPD, SNSPD |
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We have studied the influence of an externally applied magnetic field on the photon and dark count rates of meander-type niobium nitride superconducting nanowire single-photon detectors. Measurements have been performed at a temperature of 4.2 K, and magnetic fields up to 250 mT have been applied perpendicularly to the meander plane. While photon count rates are field independent at weak applied fields, they show a strong dependence at fields starting from approximately ±25 mT. This behavior, as well as the magnetic field dependence of the dark count rates, is in good agreement with the recent theoretical model of vortex-assisted photon detection and spontaneous vortex crossing in narrow superconducting lines. However, the local reduction of the superconducting free energy due to photon absorption, which is the fitting parameter in the model, increases much slower with the photon energy than the model predicts. Furthermore, changes in the free-energy during photon counts and dark counts depend differently on the current that flows through the meander. This indicates that photon counts and dark counts occur in different parts of the meander. |
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1098-0121 |
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