TY  - STD
AU  - Tiulina, V.
AU  - Iomdina, E.
AU  - Goltsman, G.
AU  - Seliverstov, S.
AU  - Sianosyan, A.
AU  - Teplyakova, K.
AU  - Rusova, A.
AU  - Zaitsev, S.
AU  - Zernii, E.
AU  - Senin, I.
PY  - 2019
DA  - 2019//
TI  - UVB promotes the initiation of uveitic inflammatory and changes in thehydration of the cornea in vivo
KW  - medicine
KW  - scheimpflug imaging
KW  - UVB
KW  - confocal microscopy
KW  - cornea
KW  - optical coherent tomography
KW  - rabbit eyes
KW  - terahertz radiation
AB  - Recently, active research has been conducted in the field of terahertz (THz) scanning of human tissues for non­invasive determination of their hydration level, which haves hown high diagnostic efficiency of this technology in various pathological conditions. Recently, we have developed a laboratory model of the facility for monitoring the state of the water balance of the cornea using THz scanning in vivo, which opens up the possibility of applying this approach in ophthalmology. The aim of the work wasto compare the results of the THz scan of the cornea with its clinical changes using the example of an experimental model of the UV­ induced keratouveitis. Anexperimental study, which included a comprehensive assessment of clinical changes in the cornea of rabbits during keratouveitis induction, revealed a decrease in the stability of the tear film, pathological changes in the corneal epithelium and stroma, as well as its anatomical and optical parameters. Comparison of data obtained in the THz scan of the cornea with tears production, optical coherence tomography and confocal microscopy showed their consistency in all observation periods, which allows us to conclude that the developed laboratory setup works and the feasibility of further research to promote the corneal hydration evaluation technology in clinical practice. Acknowledgements: Research was funded by the RSF, grant number 16­15­00255.
SN  - 2211-5463
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/2211-5463.12675
UR  - https://doi.org/10.1002/2211-5463.12675
DO  - 10.1002/2211-5463.12675
N1  - Poster P-01-040
ID  - Tiulina_etal2019
ER  -