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Author (up) Iomdina, E. N.; Seliverstov, S.; Sianosyan, A.; Teplyakova, K.; Rusova, A.; Goltsman, G. url  doi
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  Title The prospects of using the radiation for the assessment of corneal and scleral hydration Type Abstract
  Year 2016 Publication Acta Ophthalmol. Abbreviated Journal Acta Ophthalmol.  
  Volume 94 Issue Pages  
  Keywords BWO, avalanche transit‐time diode, medicine, biology  
  Abstract Purpose

An adequate water balance (hydration extent) is one of the basic factors of normal eye function, including its external shells – the cornea and the sclera. THz systems creating images in reflected beams are likely to become ideal instruments of noninvasive testing of corneal and scleral hydration degree as THz radiation is highly sensitive to water content. The paper aims at studying the transmittance and reflectance spectra of the cornea and the sclera of rabbit and human eyes, as well as those of the whole rabbit eye, in the frequency range of 0.13–0.32 THz.

Methods

The experiments were carried out on 3 corneas and 3 rabbit scleras, 2 whole rabbit eyes, and 3 human healthy adult scleras using a specially developed THz system based on reliable and easy‐to‐use continuous wave sources: a backward‐wave oscillator and an avalanche transit‐time diode.

Results

The transmittance spectra of the cornea and the sclera and the dependence of the reflection coefficient of these tissues in THz range on water percentage content were determined. Comparison of the rabbit cornea hydrated from 73.2% to 76.3% concentration by mass demonstrated an approximately linear relationship between THz reflectivity and water concentration. The decrease of free water concentration by 1% leads to a drop of the reflectance coefficient by 13%. The parameters studied displayed noticeable differences between the sclera and the cornea of rabbits and between rabbit sclera and human sclera.

Conclusions

Preliminary results demonstrate that the proposed technique, based on continuous THz radiation, may be used to create a device for noninvasive testing of corneal and scleral hydration, which has good potential of wide‐scale practical application.

The work was supported by the Russian Foundation of Basic Research (grant No.15‐29‐03843)
 
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  Series Volume Series Issue Edition  
  ISSN 1755375X ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number Serial 1333  
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